Hla selected platelets apheresis collection from a single donor platelet count 240x109dose leucocyte depleted leucocyte count donor versus pooled random donor platelet concentrates. Random donor platelets whole blood derived platelets 50 ml dose 1015 mlkg 46 units for an average adult must transfuse within 4 hours after pooling expected increment of 500010,000. Guidelines for the administration of platelets wadsworth center. This is sent to a special blood bag, which is housed inside the aphaeresis machine.
Red cells dont have hla antigens and red cell products are now leucodepleted so exposure to foreign hla is minimised. A normal whole blood donation contains a small number of platelets which can be separated into a platelet concentrate. It is approximately 200 to 400 ml and 90% of the units contain 3 x 10e11 platelets plasma units 220280 ml cryoprecipitate units 1015 ml. When bacterial culture methods of equivalent sensitivity are used simultaneously for both pwbd platelets manufactured by the u. Singledonor platelets sdps are frequently preferred over pooled randomdonor platelets rdps to reduce donor exposures and the risk for virus transmission or hla alloimmunization. Whole blood donations are collected into a closed bag system. Apheresis platelets are collected from a single donor and contain a minimum of 3 x 1011 platelets suspended in 200 to 300 ml of plasma. An adult patient typically requires 4 units of platelet concentrates for a single treatment episode. It is possible to obtain only platelets from a donor by a process called aphaeresis. Fdas guidance documents, including this guidance, do not establish legally. Visual assessment guide professional education canadian. The preparation of single donor cryoprecipitate 3 5.
Platelets express a lot of hla antigens so a platelet transfusion causes exposure to foreign hla. Often, it is possible to collect sufficient platelets from one plateletpheresis procedure to allow the collection to be split into two adult doses of platelets. This is done after adding the additive solution to the red cells, if applicable. The baby has inherited its hla type from each parent. A pool of 6 410 1 dose for an adult one unit is 1 dose for an adult leukoreduce each unit with filter post collection leukoreduced during collection multiple donor exposure per dose. However, 48 times as many platelets can be derived from just one platelet donation. For this reason, options for paediatric transfusion support are split. Others deny that donor exposure is reduced by using apc since plateletpheresis donors are allowed to donate more frequently than whole blood. Platelets random donor platelet unit 4060 ml of platelets in plasma, contains 5. Pearson and others published logistics of platelet concentrates find. Both platelet concentrates pc derived from whole blood or single donor platelets sdp obtained from a single donor by apheresis are indicated to treat acute hemorrhage secondary to thrombocytopenia or to provide prophylaxis from hemorrhage in patients with bone marrow aplasia. Blood bank guidelines and procedures mahoning valley. Efficacy and adverse events of platelet transfusion productspecific. Single donor apheresis platelet unit is equivalent to six random donor platelet packs.
Pdf logistics of platelet concentrates researchgate. Single donor can collect hlamatched or crossmatched platelets from a single donor. Clinical indications for apheresis and whole blood platelets. Two wholeblood units collected two days apart were studied from each donor in.
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